AlphaSize® A-GPC

AlphaSize® is a patented form of Alpha-GPC. It’s a powerful nootropic and choline source that has been shown to increase the brain neurotransmitter acetylcholine, increase cell to cell communication, and help with physical and mental performance. Studies have actually shown that Alpha-GPC can slow the decline of cognitive abilities in individuals with dementia from either degenerative, or vascular origin.

SerinAid® PS

SerinAid® is a patented form of PhosphatidylSerine (PS) that has been awarded two qualified health claims by the FDA for cognition. It can help the lipid bilayer of a cell by letting nutrients into the cell and clearing out potentially harmful debris. PS may also help to reduce stress by suppressing cortisol levels.

Astragin™

Astragin™ is patented ingredient composed of Panax Notoginseng Astragalus Membranaceus. It greatly increases the absorption of peptides, amino acids, fatty acids and vitamins, reduces inflammation, and even promotes cell proliferation in the body. It has also been shown to aid in the restoration and strengthening of the intestinal lining by way of epithelial cell health.

KSM-66 Ashwagandha®

Ixoreal is the industry leader in clinical trials and basic research investigating the effectiveness of ashwagandha. KSM-66 has been evaluated in 24 “Gold Standard” clinical trials. It collaborates with major academic and research institutes. All of Ixoreal-partnered clinical studies follow gold standards of substantiation: randomized, double-blind, placebo-controlled designs.

CherryPURE®

CherryPURE® Montmorencytart cherry powder is the premier tart cherry material in the marketplace and the only tart cherry source backed by two ingredient specific clinical studies.

Blueberry Fruit Extract

Our Blueberry Fruit Extract is a highly concentrated 4:1 form. This provides more of the beneficial compounds Anthocyanins and Pterostilbene. Evidence has shown that these ingredients can protect the brain, improve cognitive function, and slow the progress of cognitive decline. Blueberries have also been shown to increase nerve growth factor in the brain (NGF). NGF helps with the preserving and development of nerve cells in the brain.

Our Ingredients

BrainTree Nutrition™ is committed to honesty, trust, and transparency. The ingredients in our brain health vitamins are manufactured exceeding the highest standards of quality and safety. BrainTree Nutrition™ supplements carry the NSF Certified for Sport approval rating, ensuring that each batch is analyzed for purity and accurate dosing and that the ingredients are approved by all major sports organizations. When you purchase BrainTree Nutrition™ health supplements, you can be certain that the ingredients on the label match those in the product. Additionally, only FDA + GMP registered facilities are used for manufacturing our products.

BrainTree Nutrition™

The Science

Experience unparalleled cognitive enhancement with BrainTree Nutrition™, expertly crafted by neurologists and backed by human clinical studies. Our commitment to absolute ingredient transparency means no proprietary blends, ensuring optimally dosed ingredients for the highest effectiveness. Our supplements amplify memory retention, invigorate focus, and elevate attention span, empowering you to excel in every aspect of life. Harnessing the latest cutting-edge research in brain health, we're dedicated to maintaining unwavering quality and safety through strict testing. Trusted by top athletes and professionals alike, BrainTree Nutrition™ is your key to unlocking ultimate cognitive performance.

Research & Articles

Alpha-Glycerylphosphorycholine (Alpha-GPC)AlphaSize

  • Alberto Muratorio, Ubaldo Bonuccelli, Angelo Nuti, Noè Battistini, Stefano Passero, Vittoria Caruso, Barbara Batani, Alberto Baroni, Federico Mayer, Tiziana Sorbi, Attilio Franciosi, Gianni Moro, Luciano Agostini, Massimo Piccirilli, Diana Scatozza, A neurotropic approach to the treatment of multi-infarct dementia using L-α-glycerylphosphorylcholine,Current Therapeutic Research, Volume 52, Issue 5,1992, Pages 741-752, ISSN 0011-393X. 

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  • De Jesus Moreno Moreno, Maria. “Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.”Clinical therapeuticsvol. 25,1 (2003): 178-93. doi:10.1016/s0149-2918(03)90023-3

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  • Ziegenfuss, T., Landis, J. & Hofheins, J. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise.J Int Soc Sports Nutr5,P15 (2008). 

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Astragalus Membranaceus andPanax NotoginsengAstraGin

  • Ahmed, Mohammed S et al. “Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus.”American journal of kidney diseases : the official journal of the National Kidney Foundationvol. 50,6 (2007): 1028-32. doi:10.1053/j.ajkd.2007.07.032 

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  • Chen, Chun-Chung et al. “Chinese Herb Astragalus membranaceus Enhances Recovery of Hemorrhagic Stroke: Double-Blind, Placebo-Controlled, Randomized Study.”Evidence-based complementary and alternative medicine : eCAMvol. 2012 (2012): 708452. doi:10.1155/2012/708452 

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  • Gao, Xing-hua et al. “Qi-Shao-Shuang-Gan, a combination of Astragalus membranaceussaponins with Paeonia lactiflora glycosides, ameliorates polymicrobial sepsis induced by cecal ligation and puncture in mice.”Inflammationvol. 34,1 (2011): 10-21. doi:10.1007/s10753-010-9202-7. 

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  • Huang, Xiaoping et al. Zhongguo Zhong yao za zhi = Zhongguozhongyao zazhi = China journal of Chinese materia medicavol. 35,16 (2010): 2187-91.Tan, Hua et al.Zhong xi yi jie he xue bao = Journal of Chinese integrative medicinevol. 8,5 (2010): 448-52. doi:10.3736/jcim20100508 

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  • Xuejiang, W et al. “Antioxidant potential of qizhu tang, a chinese herbal medicine, and the effect on cerebral oxidative damage after ischemia reperfusion in rats.”Biological & pharmaceutical bulletinvol. 24,5 (2001): 558-63. doi:10.1248/bpb.24.558 

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  • Zwickey, Heather et al. “The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study.”Phytotherapy research : PTRvol. 21,11 (2007): 1109-12. doi:10.1002/ptr.220. 

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Blueberry Fruit Extract

  • Boespflug, Erin L et al. “Enhanced neural activation with blueberry supplementation in mild cognitive impairment.”Nutritional neurosciencevol. 21,4 (2018): 297-305. doi:10.1080/1028415X.2017.1287833. 

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  • Bowtell, Joanna L et al. “Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation.”Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolismevol. 42,7 (2017): 773-779. doi:10.1139/apnm-2016-0550. 

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  • Hein, Sabine et al. “Systematic Review of the Effects of Blueberry on Cognitive Performance as We Age.”The journals of gerontology. Series A, Biological sciences and medical sciencesvol. 74,7 (2019): 984-995. doi:10.1093/gerona/glz082. 

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  • Krikorian, Robert et al. “Blueberry supplementation improves memory in older adults.”Journal of agricultural and food chemistryvol. 58,7 (2010): 3996 - 4000. doi:10.1021/jf9029332. 

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  • Miller, Marshall G et al. “Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial.”European journal of nutritionvol. 57,3 (2018): 1169-1180. doi:10.1007/s00394-017-1400-8. 

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  • Rimando, Agnes M et al. “Resveratrol, pterostilbene, and piceatannol in vaccinium berries.”Journal of agricultural and food chemistryvol. 52,15 (2004): 4713-9. doi:10.1021/jf040095e. 

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  • Rimando, A.M. and Barney, D.L. (2005). RESVERATROL AND NATURALLY OCCURRING ANALOGUES IN VACCINIUM SPECIES. Acta Hortic. 680, 137-143DOI: 10.17660/ActaHortic.2005.680.20. 

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  • Rodríguez-Bonilla, Pilar et al. “Development of a reversed phase high performance liquid chromatography method based on the use of cyclodextrins as mobile phase additives to determine pterostilbene in blueberries.”Journal of chromatography. B, Analytical technologies in the biomedical and life sciencesvol. 879,15-16 (2011): 1091-7. doi:10.1016/j.jchromb.2011.03.025. 

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  • Stevenson, David and Scalzo, Jessica. ‘Anthocyanin Composition and Content of Blueberries from Around the World’. 1 Jan. 2012 : 179 –189.  

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  • Whyte, Adrian R et al. “A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and WorkingMemory in Older Adults.”Nutrientsvol. 10,6 660. 23 May. 2018, doi:10.3390/nu10060660. 

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Panax GinsengAsian Panax Ginseng Root Extract 

  • Kennedy, D.O. Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance. Sports Med 49,39–58 (2019).

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  • Kennedy, D O et al. “Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers.”Nutritional neurosciencevol. 4,5 (2001): 399-412. doi:10.1080/1028415x.2001.11747376. 

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  • Kennedy, D O et al. “Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults.”Physiology & behaviorvol. 75,5 (2002): 739-51. doi:10.1016/s0031-9384(02)00665-0. 

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  • Kennedy, D O et al. “Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng.”Pharmacology, biochemistry, and behaviorvol. 79,3 (2004): 401-11. doi:10.1016/j.pbb.2004.07.014. 

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  • Kennedy, D O et al. “Electroencephalograph effects of single doses of Ginkgo biloba and Panax ginseng in healthy young volunteers.”Pharmacology, biochemistry, and behaviorvol. 75,3 (2003): 701-9. doi:10.1016/s0091-3057(03)00120-5. 

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  • Kennedy D, Reay J, Scholey A. Effects of 8 weeks administration of KoreanPanax ginsengextract on the mood and cognitive performance of healthy individuals. J Ginseng Res. 2007;31(1):34–43.  

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  • Reay, Jonathon L et al. “Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity.”Journal of psychopharmacology (Oxford, England)vol. 19,4 (2005): 357-65. doi:10.1177/0269881105053286. 

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  • Reay, Jonathon L et al. “Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks.”Journal of psychopharmacology (Oxford, England)vol. 20,6 (2006): 771-81. doi:10.1177/0269881106061516. 

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  • Reay, Jonathon L et al. “Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults.”Human psychopharmacologyvol. 25,6 (2010): 462-71. doi:10.1002/hup.113. 

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  • Scholey, Andrew et al. “Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study.”Psychopharmacologyvol. 212,3 (2010): 345-56. doi:10.1007/s00213-010-1964-y. 

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  • Sünram-Lea, S. I.andBirchall, R.andWesnes, K. A.andPetrini, O.(2005)The effect of acute administration of400mg of Panax ginseng on cognitive performance and mood in healthy young volunteers.Current Topics in Nutraceutical Research, 3 (1). pp. 65-74. ISSN 1540 - 7535. 

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  • Ziemba, A W et al. “Ginseng treatment improves psychomotor performance at rest and during graded exercise in young athletes.”International journal of sport nutritionvol. 9,4 (1999): 371-7. doi:10.1123/ijsn.9.4.371. 

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Phosphatidylserine (PS)SerinAid

  • Crook, T et al. “Effects of phosphatidylserine in Alzheimer's disease.”Psychopharmacology bulletinvol. 28,1 (1992): 61-6.  

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  • Engel, R R et al. “Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type.”European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacologyvol. 2,2 (1992): 149-55. doi:10.1016/0924-977x(92)90025-4.

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  • Hirayama, S et al. “The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.”Journal of human nutrition and dietetics : the official journal of the British Dietetic Associationvol. 27 Suppl 2 (2014): 284-91. doi:10.1111/jhn.12090. 

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  • Jäger, Ralf et al. “The effect of phosphatidylserine on golf performance.”Journal of the International Society of Sports Nutritionvol. 4 23. 4 Dec. 2007, doi:10.1186/1550-2783-4-23. 

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  • Jorissen, B L et al. “The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment.”Nutritional neurosciencevol. 4,2 (2001): 121-34. doi:10.1080/1028415x.2001.11747356 

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  • Kato-Kataoka, Akito et al. “Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints.”Journal of clinical biochemistry and nutritionvol. 47,3 (2010): 246-55. doi:10.3164/jcbn.10-62. 

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  • Monteleone, P et al. “Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men.”European journal of clinical pharmacologyvol. 42,4 (1992): 385-8. doi:10.1007/BF00280123. 

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  • Parker, Adam G et al. “The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise.”Journal of the International Society of Sports Nutritionvol. 8 16. 21 Oct. 2011, doi:10.1186/1550-2783-8-16. 

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  • Schreiber, S et al. “An open trial of plant-source derived phosphatydilserine for treatmentof age-related cognitive decline.”The Israel journal of psychiatry and related sciencesvol. 37,4 (2000): 302-7.  

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  • Vakhapova, Veronika et al. “Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial.”Dementia and geriatric cognitive disordersvol. 29,5 (2010): 467-74.  

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